Updated in July, 2025

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About

Any statistical and computational methods operate under the constraints imposed by the data generating process. To put it another way, no method can extract information from data beyond what is given by nature. Based on this insight, I study how evolutionary processes shape statistical inference.

I’m currently working on the following topics:

• Graphical algorithms in tree sequences for scalable statistical genetics
• Phylogenetic constraints of molecular language models
• Evolutionary basis of whole-genome regression

I try to convince people that all priors of Bayesian models applied to genetic data implicitly (or explicitly) represent the underlying evolutionary process.

Contact: hblee@umich.edu

Education

University of Michigan, Ann Arbor

• Doctor of Philosophy, Department of Statistics (2024.9 -)

Seoul National University

• Doctor of Medicine, Department of Medicine (2016.3 - 2023.8)
• Bachelor of Mathematics, Department of Mathematical Sciences (2017.3 - 2023.8)

Professional service

Peer review

International Journal of Epidemiology, Nature Communications, Genetics (GSA)

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Publications

*: Equal contribution

• Preprints

  • Brieuc Lehmann, Hanbin Lee, Luke Anderson-Trocme, Jerome Kelleher, Gregor Gorjanc, and Peter L. Ralph On ARGs, pedigrees, and genetic relatedness matrices. bioRxiv, 2025
    
    
  • Hanbin Lee, Nathaniel S. Pope, Jerome Kelleher, Gregor Gorjanc, and Peter L. Ralph Modelling complex traits with ancestral recombination graphs. bioRxiv, 2025
    
    

• Journals

  • Hanbin Lee, Rosalind F. Craddock, Gregor Gorjanc, and Hannes Becher randPedPCA: Rapid approximation of principal components from large pedigrees. Genetics Selection Evolution, 2025
    Description: Pedigree contains rich information about the relationship between individuals. The rapidly growing size of pedigrees poses a computational challenge in effectively visualizing the information encoded in the pedigree. To this end, we developed randPedPCA that can run principal component analysis of millions of individuals recorded in a pedigree.
    
    
  • Hanbin Lee*, Moo Hyuk Lee*, Kangcheng Hou, Bogdan Pasaniuc, and Buhm Han Admixed and single-continental genome segments of the same ancestry have distinct linkage disequilibrium patterns. Genome Biology, 2025
    Description: We analyze two popular GWAS methods, standard GWAS and Tractor, through a population genetic lens. Admixed genomes offer higher power compared to multi-ancestry single-continental genomes of the same size if analyzed by standard GWAS, but not with Tractor. We show that linkage disequilibrium is not limited within ancestry segments of admixed genomes, making ancestry-specific Tractor estimates different from their single-continental counterparts.
    
    
  • Hanbin Lee, and Buhm Han Pseudobulk with proper offsets has the same statistical properties as generalized linear mixed models in single-cell case-control studies. Bioinformatics, 2024
    Description: By adjusting the offset of a pseudobulk method, one can produce results that are identical to generalized linear mixed models in single-cell case-control studies. Hence, the massive computational burden and convergence problems of mixed models can be avoided by using pseudobulk instead without affecting the result.
    
    
  • Hanbin Lee, and Buhm Han FastRNA: an efficient exact solution for PCA of single-cell RNA sequencing data based on a batch-accounting count model. American Journal of Human Genetics, 2022
    Description: FastRNA produces batch-corrected low-dimensional representation of single-cell RNA sequencing data. We combine (1) the theory of sufficient statistics and (2) eigendecomposition to derive a completely sparse algorithm to perform feature selection and principal component analysis (PCA). The memory consumption and runtime are two to four orders of magnitude smaller than competing methods, enabling atlas-scale scRNA-seq data analysis within an ordinary personal computer.
    
    
  • Hanbin Lee, and Buhm Han A theory-based practical solution to correct for sex-differential participation bias. Genome Biology, 2022
    Description: The paper shows that sex-differential participation bias is largely dependent to the overall participation rate of a genetic cohort under standard parameteric assumptions. The major findings are (1) selection bias is highly sensitive to the parametric choice of the participation model (2) bias due to discrete variables contributing to study participation can be mitigated through stratification under low participation rate. As a result, it raises concern on the use of commercial genetic cohorts in which the target population is poorly specified, in turn, making the overall participation rate unidentifiable.
    
    
  • Chanwoo Kim*, Hanbin Lee*, Juhee Jeong, Keehoon Jung and Buhm Han MarcoPolo: a clustering-free approach to the exploration of differentially expressed genes along with group information in single-cell RNA-seq data. Nucleic Acids Research, 2022
    Description: MarcoPolo prioritizes potentially important genes in a single-cell RNA sequencing data through a unique ranking system. The method first fits a bimodal Poisson distribution and uses the fitted attributes to generate ranks of genes using four distinct metrics. The process does not require preceeding clustering of cells so it is robust to clustering results which are sensitive to program parameters.